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Migrastatin Acts as a Muscarinic Acetylcholine Receptor Antagonist

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2006Publisher:Springer Science and Business Media LLCJournal:The Journal of Antibiotics, volume 59, pages 685-692 (issn: 0021-8820, eissn: 1881-1469,

Authors: Yoshio Nishimura; Syunichi Ohba; Koichi Nakae; Yuzuru Akamatsu;

doi: 10.1038/ja.2006.91

pmid: 17256466

Migrastatin Acts as a Muscarinic Acetylcholine Receptor Antagonist

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Abstract

Migrastatin and its analogs have various biological activities such as inhibition of cell migration and anchorage-independent growth of cancer cells. Although its biosynthesis and chemical synthesis have been under investigation, little is known about the biological target of migrastatin. Here, we found that migrastatin inhibited intracellular calcium mobilization induced by carbachol in neuroblastoma SK-N-SH cells without affecting Ca2+ mobilization and cAMP accumulation induced by ligands of other receptors. The binding of [3H] N-methylscopolamine, an antagonist for muscarinic receptor was also inhibited by migrastain. Functionally, migrastatin inhibited Ca2+ mobilization induced by carbachol in primary cultures of smooth muscle cells of rat bladder. This study reveals that migrastatin acts as a muscarinic acetylcholine receptor antagonist.

Related Organizations

Medical Research Institute
Sri Lanka

Keywords

Mice, Inbred ICR, Drinking, Muscle, Smooth, Muscarinic Antagonists, N-Methylscopolamine, Receptors, Muscarinic, Rats, Rats, Sprague-Dawley, Lactones, Mice, Cell Line, Tumor, Cyclic AMP, Animals, Humans, Calcium, Carbachol, Female, Macrolides, Cells, Cultured, Piperidones

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	21
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	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average