New Destruxins from the Marine-derived Fungus Beauveria felina
Copyright policy )New Destruxins from the Marine-derived Fungus Beauveria felina
Chemical investigation of the cytotoxic and anti-tuberculosis active butanone extract obtained from the growth media of the marine-derived fungus Beauveria felina led to the isolation of two new destruxins, [beta-Me-Pro] destruxin E chlorohydrin (1) and pseudodestruxin C (3), along with five known cyclic depsipeptides. The structures of the new destruxin derivatives were established by analysis of spectroscopic data, while the absolute configuration of the common amino acid residues was established by Marfey's analysis. The absolute configuration of the 2(R),4(S)-5-chloro-2,4-dihydroxypentanoic acid residue in 1 could be established by application of a J-based configuration method followed by derivatization with R-MPA-Cl and NMR analysis.
- UNIVERSIDADE DE SAO PAULO Brazil
- Sao Paulo State University Brazil
- State University of Campinas Brazil
- University of Utah United States
- Universidade de São Paulo Brazil
isariin b, cyclodepsipeptide, animal cell, cancer cell culture, pseudodestruxin c, roseotoxin b, proton nuclear magnetic resonance, destruxin, Mice, antibacterial activity, Antibiotics, Depsipeptides, derivatization, Amino Acids, phenylalanyl, Tumor, Antibiotics, Antineoplastic, Molecular Structure, fungus, beta methylprolyldestruxin e chlorohydrin, stereochemistry, Beauveria felina, Antineoplastic, unclassified drug, hydrolysis, priority journal, n methylvalyldestruxin b, valeric acid derivative, cytotoxicity, 2,4 5 chloro 2,4 dihydroxypentanoic acid, Marine microorganisms, spectroscopy, drug isolation, high performance liquid chromatography, roseocardin, Antitubercular, Cell Line, Fungal Proteins, Cell Line, Tumor, Animals, Humans, controlled study, human, Beauveria, Antibiotics, Antitubercular, mouse, nonhuman, human cell, Spectrum Analysis, Fungi, Mycobacterium tuberculosis, Mycotoxins, Destruxins, destruxin e chlorohydrin
isariin b, cyclodepsipeptide, animal cell, cancer cell culture, pseudodestruxin c, roseotoxin b, proton nuclear magnetic resonance, destruxin, Mice, antibacterial activity, Antibiotics, Depsipeptides, derivatization, Amino Acids, phenylalanyl, Tumor, Antibiotics, Antineoplastic, Molecular Structure, fungus, beta methylprolyldestruxin e chlorohydrin, stereochemistry, Beauveria felina, Antineoplastic, unclassified drug, hydrolysis, priority journal, n methylvalyldestruxin b, valeric acid derivative, cytotoxicity, 2,4 5 chloro 2,4 dihydroxypentanoic acid, Marine microorganisms, spectroscopy, drug isolation, high performance liquid chromatography, roseocardin, Antitubercular, Cell Line, Fungal Proteins, Cell Line, Tumor, Animals, Humans, controlled study, human, Beauveria, Antibiotics, Antitubercular, mouse, nonhuman, human cell, Spectrum Analysis, Fungi, Mycobacterium tuberculosis, Mycotoxins, Destruxins, destruxin e chlorohydrin
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