Fungal Phenalenones Inhibit HIV-1 Integrase
Copyright policy )Fungal Phenalenones Inhibit HIV-1 Integrase
A phenalenone compound, atrovenetinone methyl acetal, was isolated from a culture broth of Penicillium sp. FKI-1463 as an HIV-1 integrase inhibitor, and it showed anti-HIV activity in vitro. HIV-1 integrase inhibition and anti-HIV activity of two other natural phenalenones were also studied. Among the tested compounds, funalenone inhibited HIV-1 integrase with an IC50 value of 10 microM and showed the best selectivity (anti-HIV, IC50=1.7 microM; cytotoxicity, IC50=87 microM).
- University of Tokyo Japan
- National Institute of Health Pakistan
- National Institute of Infectious Diseases Japan
- Life Science Institute Japan
- Kitasato University Japan
Structure-Activity Relationship, Antifungal Agents, Polycyclic Compounds, HIV Integrase, Enzyme Inhibitors, Ketones, Naphthalenes, Phenalenes
Structure-Activity Relationship, Antifungal Agents, Polycyclic Compounds, HIV Integrase, Enzyme Inhibitors, Ketones, Naphthalenes, Phenalenes
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