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Article . 2012 . Peer-reviewed
License: Springer TDM
Data sources: Crossref
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Improvement in corneal scarring following bacterial keratitis

Authors: McClintic, SM; Srinivasan, M; Mascarenhas, J; Greninger, DA; Acharya, NR; Lietman, TM; Keenan, JD;

Improvement in corneal scarring following bacterial keratitis

Abstract

Bacterial keratitis results in corneal scarring and subsequent visual impairment. The long-term evolution of corneal scars has not been well described. In this case series, we identified patients who had improvement in corneal scarring and visual acuity from a clinical trial for bacterial keratitis.We searched the records of the Steroids for Corneal Ulcers Trial (SCUT) for patients who had improvement in vision between the 3-month and 12-month visits and reviewed their clinical photographs.Of the 500 patients enrolled in SCUT, five patients with large central corneal scars due to bacterial keratitis are presented. All experienced improvement in rigid contact lens-corrected visual acuity from months 3 to 12. All patients also had marked improvement in corneal opacity during the same time period. None of the patients opted to have penetrating keratoplasty.Corneal scars may continue to improve even many months after a bacterial corneal ulcer has healed. The corneal remodeling can be accompanied by considerable improvement in visual acuity, such that corneal transplantation may not be necessary.

Country
United States
Related Organizations
Keywords

SCUT, Adult, Male, Physical Injury - Accidents and Adverse Effects, Prednisolone, Clinical Trials and Supportive Activities, Eye Infections, Clinical Sciences, Immunology, Moxifloxacin, Vision Disorders, Visual Acuity, Eye, Ophthalmology & Optometry, Eye Infections, Bacterial, Pneumococcal Infections, Cicatrix, Clinical Research, Opthalmology and Optometry, Humans, Pseudomonas Infections, Corneal Ulcer, Eye Disease and Disorders of Vision, Ophthalmology and Optometry, Aged, corneal scar, Aza Compounds, Biomedical and Clinical Sciences, Bacterial, Evaluation of treatments and therapeutic interventions, Ophthalmology and optometry, Middle Aged, corneal ulcer, 6.1 Pharmaceuticals, Quinolines, Female, Ophthalmic Solutions, Fluoroquinolones

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    selected citations
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    15
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
15
Top 10%
Top 10%
Average
Green
bronze