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Experimental and Molecular Medicine
Article . 2001 . Peer-reviewed
License: Springer TDM
Data sources: Crossref
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Experimental and Molecular Medicine
Article
License: CC BY
Data sources: UnpayWall
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Cloning of BNIP3h, a member of proapoptotic BNIP3 family genes

Authors: M, Farooq; Y, Kim; S, Im; E, Chung; S, Hwang; M, Sohn; M, Kim; +1 Authors

Cloning of BNIP3h, a member of proapoptotic BNIP3 family genes

Abstract

Apoptosis is regulated by interaction of antiapoptotic Bcl-2 family proteins with various proapoptotic proteins, several of which are also members of the Bcl-2 family. BNIP3 (formerly NIP3) is a proapoptotic mitochondrial protein classified in the Bcl-2 family based on limited sequence homology-3 (BH3) domain and COOH-terminal transmembrane domain. Sequence comparison of BNIP3 has indicated that there are several BNIP3 human homologs of this protein, like BNIP3L, Nix and BNIP3. We have cloned a new member of BNIP3 family from the cDNA library prepared from human dermal papilla cells and designated as BNIP3h. BNIP3h shows substantial homology with other BNIP3 family proteins. BNIP3h induced apoptosis from 24 hours after transfection in MCF7 cell lines and its apoptosis inducing activity is extended until 72 hours after transfection.

Related Organizations
Keywords

Base Sequence, Tumor Suppressor Proteins, Molecular Sequence Data, Membrane Proteins, Apoptosis, Dermis, Transfection, Mitochondria, Multigene Family, Proto-Oncogene Proteins, Tumor Cells, Cultured, Humans, Tissue Distribution, Amino Acid Sequence, Cloning, Molecular, Sequence Alignment, Cells, Cultured

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    popularity
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    influence
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
14
Average
Top 10%
Average
gold