Immune synapses: mitochondrial morphology matters

descriptionPublicationkeyboard_double_arrow_right Article 06 Apr 2011 English Publisher:Springer Science and Business Media LLCJournal:The EMBO Journal, volume 30, pages 1,187-1,189 (issn: 0261-4189, eissn: 1460-2075,

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Authors: Christian, Junker; Markus, Hoth;

doi: 10.1038/emboj.2011.72

pmid: 21468096

pmc: PMC3094123

Immune synapses: mitochondrial morphology matters

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Abstract

Proper positioning of mitochondria is critical for cellular function. Mitochondria localization close to synapses regulates signalling at neuronal and immune synapses (ISs). Vice versa, synapses influence activity, motility and the fusion/fission balance of close‐by mitochondria. In this issue of The EMBO Journal , Baixauli et al (2011) identify a role for the mitochondrial fission factor dynamin‐related protein 1 (DRP1) at the IS. DRP1 not only controls mitochondrial fission but also mitochondrial positioning to the IS, thereby modulating IS formation and downstream signalling.

Related Organizations

Saarland University
Germany

Keywords

Dynamins, Mitochondrial Proteins, Immunological Synapses, Humans, Microtubule-Associated Proteins, GTP Phosphohydrolases, Mitochondria

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