Drosha and Dicer: Slicers cut from the same cloth

descriptionPublicationkeyboard_double_arrow_right Article 29 Apr 2016 English Publisher:Springer Science and Business Media LLCJournal:Cell Research, volume 26, pages 511-512 (issn: 1001-0602, eissn: 1748-7838,

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Authors: Sisi, Li; Dinshaw J, Patel;

doi: 10.1038/cr.2016.19

pmid: 27125999

pmc: PMC4856758

Drosha and Dicer: Slicers cut from the same cloth

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Abstract

DROSHA and its partner DGCR8 form a heterotrimeric complex named Microprocessor, which is essential for microRNA biogenesis. A recent study by Kwon et al. in Cell reveals the structure of a DROSHA construct in complex with the C-terminal region of DGCR8, thereby unveiling the topology and interactions between components of the Microprocessor and insights into its 'ruler'-based cleavage activity and function.

Related Organizations

Memorial Sloan Kettering Cancer Center
United States
Southern University of Science and Technology
China (People's Republic of)

Keywords

Ribonuclease III, MicroRNAs, Humans, RNA-Binding Proteins

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