Driving glioblastoma growth by alternative polyadenylation

descriptionPublicationkeyboard_double_arrow_right Article 04 Jul 2014 English Publisher:Springer Science and Business Media LLCJournal:Cell Research, volume 24, pages 1,023-1,024 (issn: 1001-0602, eissn: 1748-7838,

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Authors: Ting, Han; John K, Kim;

doi: 10.1038/cr.2014.88

pmid: 24993033

pmc: PMC4152745

Driving glioblastoma growth by alternative polyadenylation

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Abstract

Global shortening of 3' untranslated regions (3' UTRs) through alternative polyadenylation is an emerging hallmark of cancer. A recent study identifies the cleavage factor Im 25 (CFIm25) as an important mediator of 3' UTR shortening in glioblastomas and demonstrates a causal relationship between alternative polyadenylation and cancer cell proliferation.

Related Organizations

The University of Texas Southwestern Medical Center
United States
University of Michigan–Ann Arbor
United States
University of Michigan–Flint
United States

Keywords

Gene Expression Regulation, Neoplastic, Male, mRNA Cleavage and Polyadenylation Factors, Carcinogenesis, Animals, Humans, RNA, Messenger, Glioblastoma, Polyadenylation

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