Leucyl-tRNA synthetase: double duty in amino acid sensing
Copyright policy )Leucyl-tRNA synthetase: double duty in amino acid sensing
The cellular response to amino acids is controlled at the molecular level by TORC1. While many of the elements that participate in TORC1 signaling are known, we still have no clear idea how cells sense amino acids. Two recent studies found that leucyl-tRNA synthetase (LRS) is a leucine sensor for TORC1, in both yeast and mammalian cells.
- University of Basel Switzerland
Mammals, TOR Serine-Threonine Kinases, Mechanistic Target of Rapamycin Complex 1, Enzyme Activation, Leucine, Multiprotein Complexes, Yeasts, Protein Interaction Mapping, Animals, Humans, Leucine-tRNA Ligase, Energy Metabolism, Lysosomes, Signal Transduction
Mammals, TOR Serine-Threonine Kinases, Mechanistic Target of Rapamycin Complex 1, Enzyme Activation, Leucine, Multiprotein Complexes, Yeasts, Protein Interaction Mapping, Animals, Humans, Leucine-tRNA Ligase, Energy Metabolism, Lysosomes, Signal Transduction
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