Hunting the Hedgehog Pathway

descriptionPublicationkeyboard_double_arrow_right Article 21 Apr 2010Publisher:WileyJournal:Clinical Pharmacology & Therapeutics, volume 87, pages 743-747 (issn: 0009-9236, eissn: 1532-6535,

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Authors: G J, Weiss; D D, Von Hoff;

doi: 10.1038/clpt.2010.34

pmid: 20410878

Hunting the Hedgehog Pathway

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Abstract

Since the observation nearly 50 years ago of cyclopic newborn lambs borne by ewes grazing on California corn lily, an explosion of discovery has ensued. The Hedgehog (HH) signaling pathway is perhaps one of the most exciting targets in cancer research today. Here we provide a summary of the HH signaling pathway and detail its clinical relevance for treatment of patients and future research directions. Clinical Pharmacology & Therapeutics (2010) 87 6, 743–747. doi: 10.1038/clpt.2010.34

Related Organizations

Translational Genomics Research Institute
United States

Keywords

Clinical Trials as Topic, Antineoplastic Agents, History, 20th Century, History, 21st Century, Drug Delivery Systems, Drug Design, Neoplasms, Animals, Humans, Hedgehog Proteins, Signal Transduction

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