A quarter century of granzymes

descriptionPublicationkeyboard_double_arrow_right Article 04 Nov 2011 English Publisher:Springer Science and Business Media LLCJournal:Cell Death & Differentiation, volume 19, pages 28-35 (issn: 1350-9047, eissn: 1476-5403,

Copyright policy )Funded by:CIHR | unidentified

Authors: C L, Ewen; K P, Kane; R C, Bleackley;

doi: 10.1038/cdd.2011.153

pmid: 22052191

pmc: PMC3252830

A quarter century of granzymes

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Abstract

Granzymes (Grs) were discovered just over a quarter century ago. They are produced by cytotoxic T cells and natural killer cells and are released upon interaction with target cells. Intensive biochemical, genetic, and biological studies have been performed in order to study their roles in immunity and inflammation. This review summarizes research on the family of Grs.

Related Organizations

University of Alberta
Canada

Keywords

Inflammation, Caspase 3, Perforin, Immunity, Apoptosis, History, 20th Century, History, 21st Century, Granzymes, Killer Cells, Natural, Mice, Animals, Humans, T-Lymphocytes, Cytotoxic

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