Mutations at codon 974 of the DPYD gene are a rare event
Copyright policy )Mutations at codon 974 of the DPYD gene are a rare event
A mutation at codon 974 of the dihydropyrimidine dehydrogenase (DPD) gene was previously described in a cancer patient with undetectable DPD enzyme activity who experienced severe toxicity when treated with 5-fluorouracil. We have studied the frequency of this mutation in 29 Scottish subjects with low DPD enzyme activity and in 274 American subjects. We detected no mutations in the 606 alleles studied and conclude that mutations at codon 974 are a rare event.
- St. Jude Children's Research Hospital United States
- National Institutes of Health United States
- University of Aberdeen United Kingdom
- National Cancer Institute United States
Gene Frequency, Humans, Point Mutation, Oxidoreductases, Polymerase Chain Reaction, Dihydrouracil Dehydrogenase (NADP), Polymorphism, Restriction Fragment Length
Gene Frequency, Humans, Point Mutation, Oxidoreductases, Polymerase Chain Reaction, Dihydrouracil Dehydrogenase (NADP), Polymorphism, Restriction Fragment Length
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