An evaluation of preoperative CA 15-3 measurement in primary breast carcinoma
Copyright policy )An evaluation of preoperative CA 15-3 measurement in primary breast carcinoma
In this study of 500 patients with breast carcinoma, we have prospectively assessed the role of preoperative CA 15-3 as a marker of disease burden over a 7 year period. CA 15-3 levels at presentation correlate with stage of disease, tumour size, lymph node status, the presence of metastases and lymphocyte infiltration into the tumour. CA 15-3 alone is not an independent prognostic indicator, although a serum level of > 40 U ml(-1) has a positive predictive value of 83% for the presence of advanced disease. We recommend the routine use of this marker in the preoperative assessment of primary breast carcinoma.
- University Hospital Galway Ireland
- University of Galway Ireland
- Health Service Executive Ireland
- University College Hospital United Kingdom
- Saolta University Health Care Group Ireland
tumors, ca15-3, monoclonal-antibodies, Breast Neoplasms, Enzyme-Linked Immunosorbent Assay, Sensitivity and Specificity, Predictive Value of Tests, Humans, ca 15-3, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasm Staging, Externally hosted open access publications with University of Galway authors, breast neoplasia, Mucin-1, Middle Aged, df3, Postmenopause, antigen levels, Premenopause, Receptors, Estrogen, Lymphatic Metastasis, tumor marker, Female, cancer patients
tumors, ca15-3, monoclonal-antibodies, Breast Neoplasms, Enzyme-Linked Immunosorbent Assay, Sensitivity and Specificity, Predictive Value of Tests, Humans, ca 15-3, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasm Staging, Externally hosted open access publications with University of Galway authors, breast neoplasia, Mucin-1, Middle Aged, df3, Postmenopause, antigen levels, Premenopause, Receptors, Estrogen, Lymphatic Metastasis, tumor marker, Female, cancer patients
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