Bleomycin and misonidazole cytotoxicity

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1985 English Publisher:Springer Science and Business Media LLCJournal:British Journal of Cancer, volume 51, pages 499-504 (issn: 0007-0920, eissn: 1532-1827,

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Authors: M, Korbelik; B, Palcic; L D, Skarsgard;

doi: 10.1038/bjc.1985.72

pmid: 2579666

pmc: PMC1977142

Bleomycin and misonidazole cytotoxicity

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Abstract

Chinese hamster ovary (CHO) cells were exposed in vitro to combinations of bleomycin and misonidazole under hypoxic conditions. Only one drug was present at any given time and cells were washed before being exposed to the second drug. Both drugs induced potentially lethal damage (PLD). This damage was repaired under hypoxic conditions very rapidly, and bleomycin-induced PLD was repaired more rapidly than misonidazole-induced PLD. If, after the combined treatment, cells are kept in hypoxia, much of the damage can be repaired.

Keywords

Cell Survival, Ovary, Drug Synergism, Oxygen, Bleomycin, Cricetulus, Nitroimidazoles, Cricetinae, Animals, Female, Misonidazole, Cells, Cultured

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