Glial fibrillary acidic protein in tumours of the nervous system

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1978 English Publisher:Springer Science and Business Media LLCJournal:British Journal of Cancer, volume 37, pages 33-40 (issn: 0007-0920, eissn: 1532-1827,

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Authors: B, Delpech; A, Delpech; M N, Vidard; N, Girard; J, Tayot; J C, Clement; P, Creissard;

doi: 10.1038/bjc.1978.5

pmid: 339941

pmc: PMC2009497

Glial fibrillary acidic protein in tumours of the nervous system

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Abstract

Glial fibrillary acidic protein (GFA) was assayed in nerve-tumour extracts and located in these tumours by indirect immunofluorescence study. We conclude that GFA is a specific marker of both malignant and normal astrocytes. Non-astrocytic tumours (oligodendroglioma, meningioma) do not contain GFA. Tumours with astrocytic differentiation potential (medulloblastoma) may contain GFA. Comparison of microscopic and GFA assays leads us to conclude that GFA concentration is proportional to the amount of malignant astrocytes in the tumour and inversely proportional to the necrotic area of a tumour. Normal tissue GFA and glioblastoma GFA were found to be immunologically identical.

Related Organizations

Hôpital Charles-Nicolle
France
Centre Hospitalier Universitaire de Rouen
France
Hôpital Charles-Nicolle
Tunisia

Keywords

Brain Neoplasms, Astrocytes, Oligodendroglioma, Fluorescent Antibody Technique, Humans, Nerve Tissue Proteins, Antigens, Astrocytoma, Medulloblastoma

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