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Adenosine deaminase activity in leukaemia

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1975Publisher:Springer Science and Business Media LLCJournal:British Journal of Cancer, volume 31, pages 544-549 (issn: 0007-0920, eissn: 1532-1827,

Authors: J F Smyth; K R Harrap;

doi: 10.1038/bjc.1975.95

pmid: 1057444

pmc: PMC2009433

Adenosine deaminase activity in leukaemia

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Abstract

Adenosine deaminase (EC 3.5.4.4., ADA) has been measured in the blast cells of 36 patients with acute lymphoblastic, acute myeloid, chronic myeloid and chronic myeloid blast crisis leukaemia. Particularly high levels were found in acute lymphoblastic and chronic myeloid blast crisis patients. The measurement of ADA may be useful diagnostically in the undifferentiated acute leukaemias and in detecting the early onset of blast crisis in chronic myeloid leukaemia. Possible reasons for the elevation of ADA in malignant cells are discussed.

Related Organizations

Institute of Cancer Research
United Kingdom
The Institute of Cancer Research
The Institute of Cancer Research
United Kingdom

Keywords

Leukemia, Myeloid, Acute, Leukemia, Adenosine Deaminase, Leukemia, Myeloid, Humans, Nucleoside Deaminases, Leukemia, Lymphoid

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	142
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%