Reversal of synaptic vesicle docking at central synapses

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1999 English Publisher:Springer Science and Business Media LLCJournal:Nature Neuroscience, volume 2, pages 503-507 (issn: 1097-6256, eissn: 1546-1726,

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Authors: V N, Murthy; C F, Stevens;

doi: 10.1038/9149

pmid: 10448213

Reversal of synaptic vesicle docking at central synapses

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Abstract

We used quantitative fluorescence imaging of vesicles labeled with membrane-soluble dyes to determine rates of undocking and spontaneous exocytosis of vesicles docked to the active zone of hippocampal synapses in culture. Individual vesicles undock about once per two minutes and spontaneously exocytose about once per eight minutes. Thus, not only does undocking occur, but it is over threefold faster than spontaneous fusion.

Related Organizations

Howard Hughes Medical Institute
United States
Harvard University
United States

Keywords

Quaternary Ammonium Compounds, Time Factors, Synapses, Pyridinium Compounds, Synaptic Vesicles, Hippocampus, Cells, Cultured, Electric Stimulation, Exocytosis, Fluorescent Dyes

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