Interleukin 12 and autoimmune diabetes
Copyright policy )Interleukin 12 and autoimmune diabetes
Interleukin 12 (IL-12) has been implicated in the pathogenesis of type 1 diabetes in the non-obese diabetic (NOD) mouse. Following this lead, a new locus associated with human type 1 diabetes, IDDM18, has been identified near the gene encoding the p40 subunit of interleukin 12 (IL12B). This finding has potential implications for the prediction of at-risk individuals and, perhaps, for the implementation of prevention strategies relevant to several autoimmune diseases.
- Roche (Italy) Italy
- Roche (Switzerland) Switzerland
Mice, Diabetes Mellitus, Type 1, Mice, Inbred NOD, Models, Immunological, Animals, Humans, Genetic Predisposition to Disease, Interleukin-12, Autoimmune Diseases
Mice, Diabetes Mellitus, Type 1, Mice, Inbred NOD, Models, Immunological, Animals, Humans, Genetic Predisposition to Disease, Interleukin-12, Autoimmune Diseases
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