Hepatocyte migration during liver development requires Prox1

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2000 English Publisher:Springer Science and Business Media LLCJournal:Nature Genetics, volume 25, pages 254-255 (issn: 1061-4036, eissn: 1546-1718,

Copyright policy )Funded by:NIH | Cancer Center Support Gra..., NIH | Homeobox Gene Six3 in For..., NIH | PROX 1 DURING MURINE CELL...

Authors: B, Sosa-Pineda; J T, Wigle; G, Oliver;

doi: 10.1038/76996

pmid: 10888866

Hepatocyte migration during liver development requires Prox1

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Abstract

Several genes are required during the early phases of liver specification, proliferation and differentiation. Here we report that Prox1 is required for hepatocyte migration. Loss of Prox1 leads to formation of a smaller liver with a reduced population of clustered hepatocytes surrounded by a laminin-rich basal membrane.

Related Organizations

St. Jude Children's Research Hospital
United States

Keywords

Homeodomain Proteins, Mice, Liver, Cell Movement, Prospero-Related Homeobox 1 Protein, Tumor Suppressor Proteins, Animals

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