Lifetime of plasma cells in the bone marrow

descriptionPublicationkeyboard_double_arrow_right Article 10 Jul 1997 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 388, pages 133-134 (issn: 0028-0836, eissn: 1476-4687,

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Authors: R A, Manz; A, Thiel; A, Radbruch;

doi: 10.1038/40540

pmid: 9217150

Lifetime of plasma cells in the bone marrow

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Abstract

Immune protection is based on long-lived memory cells and effector cells, which are either cytotoxic or secrete antibodies. The lifespan of these effector cells has not so far been determined. Here we show that antibody-secreting plasma cells from bone marrow are as long-lived as memory B cells.

Related Organizations

University of Cologne
Germany

Keywords

B-Lymphocytes, Mice, Inbred BALB C, Cell Survival, Ovalbumin, Plasma Cells, Immunization, Secondary, Bone Marrow Cells, Mice, Bromodeoxyuridine, Immunoglobulin G, Animals, Lymphocyte Count, Immunologic Memory

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