Crystal structure of cyclin-dependent kinase 2
Copyright policy )Crystal structure of cyclin-dependent kinase 2
Cyclin-dependent kinase 2 (CDK2) is a member of a highly conserved family of protein kinases that regulate the eukaryotic cell cycle. The crystal structures of the human CDK2 apoenzyme and its Mg2+ ATP complex have been determined to 2.4 A resolution. The structure is bi-lobate, like that of the cyclic AMP-dependent protein kinase, but contains a unique helix-loop segment that interferes with ATP and protein substrate binding and probably plays a key part in the regulation of all cyclin-dependent kinases.
- University of California, San Francisco United States
- University of California, Berkeley United States
Models, Molecular, Binding Sites, Crystallography, Protein Conformation, Cyclin-Dependent Kinase 2, Molecular Sequence Data, Protein Serine-Threonine Kinases, Cyclin-Dependent Kinases, Adenosine Triphosphate, Cyclins, CDC2-CDC28 Kinases, Humans, Computer Simulation, Amino Acid Sequence, Phosphorylation, Protein Kinases
Models, Molecular, Binding Sites, Crystallography, Protein Conformation, Cyclin-Dependent Kinase 2, Molecular Sequence Data, Protein Serine-Threonine Kinases, Cyclin-Dependent Kinases, Adenosine Triphosphate, Cyclins, CDC2-CDC28 Kinases, Humans, Computer Simulation, Amino Acid Sequence, Phosphorylation, Protein Kinases
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