Clonogenic cytotoxicity testing by microdrop encapsulation

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1993 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 363, pages 189-190 (issn: 0028-0836, eissn: 1476-4687,

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Authors: B, Goguen; N, Kedersha;

doi: 10.1038/363189a0

pmid: 8483506

Clonogenic cytotoxicity testing by microdrop encapsulation

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Abstract

Cytotoxicity is defined as the in situ measurement of cellular function in response to a toxic substance. Cytotoxicity assays are widely used in drug screening and development research to minimize the number of compounds on which expensive mammalian animal model toxicology studies are performed.

Related Organizations

ImmunoGen, Inc.
United States

Keywords

Colony-Forming Units Assay, Cytotoxins, Sepharose, Cell Adhesion, Tumor Cells, Cultured, Dimethylpolysiloxanes, Flow Cytometry, Toxicology, Gels

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