Antigen processing by the proteasome

Name: Antigen processing by the proteasome
Creator: P M, Kloetzel
Keywords: Models, Molecular, 0301 basic medicine, Antigen Presentation, Cysteine Endopeptidases, Proteasome Endopeptidase Complex, 0303 health sciences, 03 medical and health sciences, Multienzyme Complexes, Antigens, Ubiquitins

P M, Kloetzel

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Nature Reviews Molec...arrow_drop_down

Nature Reviews Molecular Cell Biology

Article . 2001 . Peer-reviewed

License: Springer TDM

Data sources: Crossref

Nature Reviews Molecular Cell Biology

Article . 2001

Data sources: Europe PubMed Central

https://dx.doi.org/10.1038/350...

Article

Data sources: Microsoft Academic Graph

Antigen processing by the proteasome

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2001 English Publisher:Springer Science and Business Media LLCJournal:Nature Reviews Molecular Cell Biology, volume 2, pages 179-188 (issn: 1471-0072, eissn: 1471-0080,

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Authors: P M, Kloetzel;

doi: 10.1038/35056572

pmid: 11265247

Antigen processing by the proteasome

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Abstract

The proteasome is an essential part of our immune surveillance mechanisms: by generating peptides from intracellular antigens it provides peptides that are then 'presented' to T cells. But proteasomes--the waste-disposal units of the cell--typically do not generate peptides for antigen presentation with high efficiency. How, then, does the proteasome adapt to serve the immune system well?

Related Organizations

Humboldt-Universität zu Berlin
Germany

Keywords

Models, Molecular, Antigen Presentation, Cysteine Endopeptidases, Proteasome Endopeptidase Complex, Multienzyme Complexes, Antigens, Ubiquitins

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