Sequence and expression of a metabotropic glutamate receptor
Copyright policy )Sequence and expression of a metabotropic glutamate receptor
The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains. Abundant expression of this messenger RNA is observed in neuronal cells in hippocampal dentate gyrus and CA2-3 and in cerebellar Purkinje cells, suggesting the importance of this receptor in specific hippocampal and cerebellar functions.
- Kyoto University Japan
Base Sequence, Protein Conformation, Xenopus, Molecular Sequence Data, Nucleic Acid Hybridization, Rats, Receptors, Neurotransmitter, Electrophysiology, Models, Structural, Glutamates, Receptors, Glutamate, Cerebellum, Sequence Homology, Nucleic Acid, Oocytes, Animals, Female, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular
Base Sequence, Protein Conformation, Xenopus, Molecular Sequence Data, Nucleic Acid Hybridization, Rats, Receptors, Neurotransmitter, Electrophysiology, Models, Structural, Glutamates, Receptors, Glutamate, Cerebellum, Sequence Homology, Nucleic Acid, Oocytes, Animals, Female, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular
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