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CCR5 is characteristic of Th1 lymphocytes

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1998Publisher:Springer Science and Business Media LLCJournal:Nature, volume 391, pages 344-345 (issn: 0028-0836, eissn: 1476-4687,

Authors: Marco Baggiolini; Bernhard Moser; Jean-Michel Dayer; Mariagrazia Uguccioni; Pius Loetscher; Carlo Chizzolini; Lorenza Bordoli;

doi: 10.1038/34814

pmid: 9450746

CCR5 is characteristic of Th1 lymphocytes

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Abstract

CD4+ lymphocytes can be assigned to two subsets1. Th1 lymphocytes secrete interferon gamma (IFNγ) and lymphotoxin, promoting cell-mediated immunity to intracellular pathogens; and Th2 lymphocytes secrete interleukins 4 and 5 (IL-4 and IL-5), which function in allergy and humoral immunity to parasites. Th2 lymphocytes preferentially express the chemokine receptor CCR3 (23). We have studied the occurrence of two additional chemokine receptors, CCR5 and CXCR3, in human, antigen-specific CD4+ Th1 and Th2 cell clones4.

Related Organizations

University of Bern
Switzerland
University Hospital of Bern
Switzerland

Keywords

Receptors, CXCR3, Receptors, CCR5, Th1 Cells, Fetal Blood, Lymphocyte Activation, Clone Cells, Arthritis, Rheumatoid, Th2 Cells, Humans, Receptors, Chemokine

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	821
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 0.1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 0.1%