Structure of the human class I histocompatibility antigen, HLA-A2
Copyright policy )Structure of the human class I histocompatibility antigen, HLA-A2
The class I histocompatibility antigen from human cell membranes has two structural motifs: the membrane-proximal end of the glycoprotein contains two domains with immunoglobulin-folds that are paired in a novel manner, and the region distal from the membrane is a platform of eight antiparallel beta-strands topped by alpha-helices. A large groove between the alpha-helices provides a binding site for processed foreign antigens. An unknown 'antigen' is found in this site in crystals of purified HLA-A2.
- Stanford University United States
- Howard Hughes Medical Institute United States
- Harvard University United States
Models, Molecular, Binding Sites, Protein Conformation, Membrane Proteins, HLA Antigens, HLA-A2 Antigen, Computer Graphics, Animals, Humans, Antigens, beta 2-Microglobulin, Glycoproteins, Protein Binding
Models, Molecular, Binding Sites, Protein Conformation, Membrane Proteins, HLA Antigens, HLA-A2 Antigen, Computer Graphics, Animals, Humans, Antigens, beta 2-Microglobulin, Glycoproteins, Protein Binding
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