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Interaction of antibiotics with functional sites in 16S ribosomal RNA

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1987Publisher:Springer Science and Business Media LLCJournal:Nature, volume 327, pages 389-394 (issn: 0028-0836, eissn: 1476-4687,

Authors: Danesh Moazed; Harry F. Noller;

doi: 10.1038/327389a0

pmid: 2953976

Interaction of antibiotics with functional sites in 16S ribosomal RNA

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Abstract

Chemical footprinting shows that several classes of antibiotics (streptomycin, tetracycline, spectinomycin, edeine, hygromycin and the neomycins) protect concise sets of highly conserved nucleotides in 16S ribosomal RNA when bound to ribosomes. These findings have strong implications for the mechanism of action of these antibiotics and for the assignment of functions to specific structural features of 16S rRNA.

Related Organizations

University of California, Santa Cruz
United States

Keywords

Spectinomycin, Base Sequence, Edeine, Tetracycline, Anti-Bacterial Agents, Aminoglycosides, Cinnamates, RNA, Ribosomal, Streptomycin, Nucleic Acid Conformation, Hygromycin B

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