Hypervariable ‘minisatellite’ regions in human DNA

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1985 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 314, pages 67-73 (issn: 0028-0836, eissn: 1476-4687,

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Authors: A J, Jeffreys; V, Wilson; S L, Thein;

doi: 10.1038/314067a0

pmid: 3856104

Hypervariable ‘minisatellite’ regions in human DNA

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Abstract

The human genome contains many dispersed tandem-repetitive 'minisatellite' regions detected via a shared 10-15-base pair 'core' sequence similar to the generalized recombination signal (chi) of Escherichia coli. Many minisatellites are highly polymorphic due to allelic variation in repeat copy number in the minisatellite. A probe based on a tandem-repeat of the core sequence can detect many highly variable loci simultaneously and can provide an individual-specific DNA 'fingerprint' of general use in human genetic analysis.

Related Organizations

Oxford University Hospitals NHS Trust
United Kingdom
John Radcliffe Hospital
United Kingdom
University of Leicester
United Kingdom
MRC Molecular Haematology Unit
United Kingdom

Keywords

Recombination, Genetic, Heterozygote, Polymorphism, Genetic, Base Sequence, Genetic Variation, Nucleic Acid Hybridization, DNA, Satellite, Pedigree, Mutation, Humans, Genetic Engineering, Alleles, Repetitive Sequences, Nucleic Acid

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