Structure of human factor VIII

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1984 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 312, pages 337-342 (issn: 0028-0836, eissn: 1476-4687,

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Authors: G A, Vehar; B, Keyt; D, Eaton; H, Rodriguez; D P, O'Brien; F, Rotblat; H, Oppermann; +6 Authors

doi: 10.1038/312337a0

pmid: 6438527

Structure of human factor VIII

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Abstract

The deduced amino acid sequence of human factor VIII, obtained from the DNA sequence, predicts a mature polypeptide of 2,332 amino acids containing a triplicated domain structure. The polypeptide has 35% sequence homology with the copper-binding plasma protein, ceruloplasmin. Determination of the thrombin cleavage sites in plasma-derived factor VIII polypeptides allows prediction of the domains involved in the associated activation and inactivation of the protein.

Related Organizations

GENENTECH INC
United States
The Royal Free Hospital
United Kingdom
Royal Free London NHS Foundation Trust
United Kingdom

Keywords

Factor VIII, Protein Conformation, Thrombin, Ceruloplasmin, Humans, Amino Acid Sequence, Protein Precursors, Peptide Fragments

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