Microtubule assembly nucleated by isolated centrosomes

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1984 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 312, pages 232-237 (issn: 0028-0836, eissn: 1476-4687,

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Authors: T, Mitchison; M, Kirschner;

doi: 10.1038/312232a0

pmid: 6504137

Microtubule assembly nucleated by isolated centrosomes

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Abstract

Microtubules are involved in the morphogenesis of most cells and are the structural basis of the mitotic spindle. We report here that purified centrosomes nucleate the assembly of microtubules with unusual dynamic properties. This may have important implications for the mechanism by which microtubule arrays are organized and stabilized in cells.

Related Organizations

University of California, San Francisco
United States

Keywords

Mice, Cell-Free System, Polymers, Tubulin, Morphogenesis, Animals, Microtubules, Centrioles, Protein Binding

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