Kinked DNA in crystalline complex with EcoRI endonuclease
Copyright policy )Kinked DNA in crystalline complex with EcoRI endonuclease
The 3 A electron density map of a co-crystalline recognition complex between EcoRI endonuclease and the oligonucleotide TCGCGAATTCGCG reveals that a tight, complementary interface between the enzyme and the major groove of the DNA is the major determinant of sequence specificity. The DNA contains a torsional kink and other departures from the B conformation which unwind the DNA and thereby widen the major groove in the recognition site.
- University of Pittsburgh United States
- University of California, San Francisco United States
- Veterans Health Administration United States
Models, Molecular, Structure-Activity Relationship, Base Sequence, Oligodeoxyribonucleotides, Nucleic Acid Conformation, DNA, DNA Restriction Enzymes, Deoxyribonuclease EcoRI, Protein Binding
Models, Molecular, Structure-Activity Relationship, Base Sequence, Oligodeoxyribonucleotides, Nucleic Acid Conformation, DNA, DNA Restriction Enzymes, Deoxyribonuclease EcoRI, Protein Binding
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).330 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 0.1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.1%
Citations provided by BIP!Popularity provided by BIP!