Transcription sans TBP

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1998 United States English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 393, pages 114-115 (issn: 0028-0836, eissn: 1476-4687,

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Authors: Apone, Lynne Marie; Green, Michael R.;

doi: 10.1038/30097

handle: 20.500.14038/33820

Transcription sans TBP

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Abstract

Several general ‘rules’ have emerged over the years about the requirements for transcription of genes. One of these was that the TATA-binding protein (TBP) is essential, both for initiation of transcription by recognizing the promoter, and for assembly of transcription complexes. A new study looks set to overturn this dogma by identifying a complex that does not contain TBP (the so-called TBP-free TAFII-containing complex, TFTC) yet can still support transcription.

Country

United States

Related Organizations

Howard Hughes Medical Institute
United States
University of Massachusetts Medical School
United States
University of Massachusetts System
United States

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