Transmission of hormonal stimulation by cell-to-cell communication

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1978 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 272, pages 501-506 (issn: 0028-0836, eissn: 1476-4687,

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Authors: T S, Lawrence; W H, Beers; N B, Gilula;

doi: 10.1038/272501a0

pmid: 211417

Transmission of hormonal stimulation by cell-to-cell communication

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Abstract

Rat ovarian granulosa cells and mouse myocardial cells respond to cell-specific hormones by cyclic AMP-dependent mechanisms. In coculture, these heterologous cells communicate by means of gap junctions. Exposure of the cocultures to a hormone specific for one cell type causes the heterologous cells to respond through a cell contact-dependent mechanism. These studies suggest that this cross-stimulation results from the intercellular communication of a mediator that is common to both cell types. The communicated mediator may be cyclic AMP.

Related Organizations

Rockefeller University
United States

Keywords

Granulosa Cells, Dose-Response Relationship, Drug, Myocardium, Cell Communication, Myocardial Contraction, Membrane Potentials, Norepinephrine, Plasminogen Activators, Intercellular Junctions, Cyclic AMP, Female, Follicle Stimulating Hormone, Cells, Cultured

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