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Histamine blocking agent in the salivary gland homogenate of the tick Rhipicephalus sanguineus sanguineus

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1977Publisher:Springer Science and Business Media LLCJournal:Nature, volume 265, pages 366-367 (issn: 0028-0836, eissn: 1476-4687,

Authors: E. Ayitey-Amith; W. A. Chinery;

doi: 10.1038/265366a0

pmid: 834285

Histamine blocking agent in the salivary gland homogenate of the tick Rhipicephalus sanguineus sanguineus

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Abstract

STUDIES of reactivity to tick bites and tick salivary gland homogenate have revealed responses similar to those induced by histamine in the skin of lop-eared rabbits2. Salivary gland homogenates of the tick Rhipicephalus sanguineus sanguineus, however, did not cause contraction of guinea pig ileum, but blocked the action of histamine acid phosphate (HAP). We have therefore tested this extract against other drugs known to cause contraction of guinea pig ileum in order to discover the spectrum of its blocking effect on this tissue. We have found that the salivary gland homogenate of this tick antagonises and potentiates, respectively, the action of histamine and acetylcholine on guinea pig ileum.

Keywords

Ticks, Ileum, Histamine Antagonists, Drug Synergism, Acetylcholine, Salivary Glands, Muscle Contraction

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