Model for action of local anaesthetics

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1976 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 262, pages 545-548 (issn: 0028-0836, eissn: 1476-4687,

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Authors: A G, Lee;

doi: 10.1038/262545a0

pmid: 958412

Model for action of local anaesthetics

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Abstract

Sodium channels in nerve membranes are postulated to be surrounded by lipid molecules in the gel (or crystalline) phase. Addition of local anasethetics triggers a change in the surrounding lipids to the fluid, liquid crystalline phase, allowing the sodium channel to close with resulting local anaesthesia. The experimental evidence for this model is discussed.

Related Organizations

University of Southampton
United Kingdom

Keywords

Neurons, Chemical Phenomena, Chemistry, Physical, Cell Membrane, Models, Neurological, Sodium, Proteins, Anesthetics, Local, Lipids

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