Production of yeast alcohol dehydrogenase isoenzymes by selection

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1976 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 261, pages 26-29 (issn: 0028-0836, eissn: 1476-4687,

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Authors: C, Wills;

doi: 10.1038/261026a0

pmid: 179008

Production of yeast alcohol dehydrogenase isoenzymes by selection

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Abstract

Mutants of yeast alcohol dehydrogenase have been produced that protect the cell against the poisonous aldehyde acrolein by increasing the NADH-NAD ratio. The altered properties include changes both in binding constants and in cooperativity. Such mutants may be useful in exploring the nature of adaptation at the molecular level.

Related Organizations

University of California, San Diego
United States
University of California, San Diego
United States

Keywords

Isoenzymes, Alcohol Oxidoreductases, Kinetics, Genes, Mutation, Saccharomyces cerevisiae, NAD, Biological Evolution

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