
doi: 10.1038/258260a0
pmid: 1202358
THE tropomyosin–troponin complex renders actomyosin from vertebrate skeletal muscle calcium sensitive. Troponin itself consists of three subunits: troponin I (TNI), troponin C (TNC) and troponin T (TNT)1. Pure TNI (24,000-dalton subunit) inhibits the actin–myosin interaction irrespective of calcium concentration. TNC (18,000-dalton subunit) binds calcium and releases the TNI imposed inhibition. TNT (37,000-dalton subunit) attaches the subunit complex to tropomyosin. Actin, myosin and tropomyosin have been isolated and characterised from a number of non-muscle cells2,3. We now describe the isolation and characterisation of a protein from chick embryo brain which is very similar to muscle TNC.
Brain Chemistry, Animals, Muscle Proteins, Chick Embryo, Amino Acids, Troponin
Brain Chemistry, Animals, Muscle Proteins, Chick Embryo, Amino Acids, Troponin
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