Heterotransplantation of Theileria parva-infected cells to athymic mice

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1975 United States English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 253, pages 549-550 (issn: 0028-0836, eissn: 1476-4687,

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Authors: Irvin, A D; Stagg, D A; Kanhai, G K; Brown, C G;

doi: 10.1038/253549a0

pmid: 804142

Heterotransplantation of Theileria parva-infected cells to athymic mice

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Abstract

CONGENITALLY athymic (nude) mice have been used for the heterotransplantation and maintenance of human tumours1–6. In many cases aplasia of the thymus is sufficient to allow tumour growth and other immunosuppressive treatments are apparently unnecessary. Here we describe how infected cells taken from a fatal case of East Coast fever (ECF), regularly produced tumour-like masses only in irradiated athymic mice.

Country

United States

Related Organizations

Jackson Laboratory
United States
United Nations Development Programme
United States

Keywords

Immunosuppression Therapy, Transplantation:, Other Parasites:, Transplantation, Heterologous, Genes: nu - Nude, Thymus Gland, Theileriasis, Mice, Lymphocyte Transfusion, Radiation Chimera, Animals, Pathology:, Cattle, Lymphocytes, Serology:, Apicomplexa

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