Different effector cell types in antibody-dependent cell-mediated cytotoxicity

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1975 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 253, pages 376-377 (issn: 0028-0836, eissn: 1476-4687,

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Authors: C J, Sanderson; I A, Clark; G A, Taylor;

doi: 10.1038/253376a0

pmid: 803302

Different effector cell types in antibody-dependent cell-mediated cytotoxicity

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Abstract

ANTIBODY-DEPENDENT cell-mediated cytotoxicity has been demonstrated in vitro using a number of continuously cultivated cell lines1,2 and nucleated erythrocytes3 as targets. Although the biological role of this cytotoxicity is not yet clear, it represents a potentially efficient cytotoxic mechanism and considerable interest has been shown in the characterisation of the effector cells.

Keywords

Immunity, Cellular, Mice, Inbred BALB C, Erythrocytes, Iron, Mast-Cell Sarcoma, Serum Albumin, Bovine, Cell Separation, Cytotoxicity Tests, Immunologic, Antibodies, Cell Line, Rats, Mice, Phagocytosis, Centrifugation, Density Gradient, Animals, Amnion, Lymphocytes, Spleen

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