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Methylation of 16S RNA during ribosome assembly in vitro

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1974Publisher:Springer Science and Business Media LLCJournal:Nature, volume 251, pages 682-686 (issn: 0028-0836, eissn: 1476-4687,

Authors: William A. Held; Pallaiah Thammana;

doi: 10.1038/251682a0

pmid: 4610401

Methylation of 16S RNA during ribosome assembly in vitro

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Abstract

Methyl deficient 16S RNA from kasugamycin resistant Escherichia coli has been used to study methylation of RNA during ribosome assembly in vitro. Methylation occurs at an intermediate stage and is inhibited at a late stage of assembly. 30S ribosomal proteins required for methylation, and inhibition, have been identified.

Related Organizations

University of Wisconsin–Oshkosh
United States

Keywords

tRNA Methyltransferases, Drug Resistance, Microbial, Methylation, Anti-Bacterial Agents, RNA, Bacterial, Aminoglycosides, Bacterial Proteins, RNA, Ribosomal, Escherichia coli, Inositol

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