pH-dependent conformational change of gastrin
Copyright policy )pH-dependent conformational change of gastrin
GASTRIN is a polypeptide hormone with a broad spectrum of biological activities, most notably the stimulation of secretion of gastric acid1,2. It is produced primarily in the pyloric gland area of the lower segment of the stomach, the antrum, which does not secrete acid1,2. When carried by the blood to the upper segment of the stomach, the fundus, gastrin stimulates secretion of acid by the oxyntic glands1. Although release of gastrin into the blood stream is mediated by stimuli from the nervous system, its release is strongly inhibited when the antral mucosa is bathed in acid2. Therefore, the secretion of the hormone is under negative feedback regulation, with resultant control of stomach acidity.
- University of California, Irvine United States
Kinetics, Structure-Activity Relationship, Models, Chemical, Protein Conformation, Circular Dichroism, Gastrins, Humans, Amino Acids, Hydrogen-Ion Concentration
Kinetics, Structure-Activity Relationship, Models, Chemical, Protein Conformation, Circular Dichroism, Gastrins, Humans, Amino Acids, Hydrogen-Ion Concentration
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