Rifampicin Poxvirus and Trachoma Agent: Rifampicin and Poxvirus Replication

descriptionPublicationkeyboard_double_arrow_right Article 04 Oct 1969 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 224, pages 29-32 (issn: 0028-0836, eissn: 1476-4687,

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Authors: ZVI BEN-ISHAI; EMMANUEL HELLER; NATAN GOLDBLUM; YECHIEL BECKER;

doi: 10.1038/224029a0

Rifampicin Poxvirus and Trachoma Agent: Rifampicin and Poxvirus Replication

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Abstract

Rifampicin appears to inhibit the replication of poxvirus by blocking the synthesis of virus protein late in the growth cycle. The antibiotic inhibits the multiplication of trachoma agent in vitro, and in vivo; it has been used successfully to treat trachoma infection of a baboon's eye. The hydrazone side-chain of rifampicin appears to be essential for its anti-viral and anti-trachomal activity.

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Hebrew University of Jerusalem
Israel

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