Prostaglandin Antagonists: Synthesis and Smooth Muscle Activity

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1969 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 223, pages 208-210 (issn: 0028-0836, eissn: 1476-4687,

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Authors: J, Fried; T S, Santhanakrishnan; J, Himizu; C H, Lin; S H, Ford; B, Rubin; E O, Grigas;

doi: 10.1038/223208a0

pmid: 4978240

Prostaglandin Antagonists: Synthesis and Smooth Muscle Activity

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Abstract

WE report here the synthesis of substances, structurally related to the prostaglandins, capable of selectively antagonizing the smooth muscle effects of both prostaglandins E1 and F1α. The availability of specific antagonists of prostaglaiidin may help solve problems about the physiological roles of the prostaglandins1.

Related Organizations

University of Chicago
United States
Bristol-Myers Squibb (United States)
United States

Keywords

Prostaglandin Antagonists, Colon, Duodenum, Receptors, Drug, Guinea Pigs, Muscle, Smooth, Acetylcholine, Ileum, Prostaglandins, Animals, Rabbits, Gerbillinae, Drug Antagonism, Histamine

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