Mechanism of Action of Aldosterone
Copyright policy )Mechanism of Action of Aldosterone
ALDOSTERONE stimulates sodium transport across some epithelia including the distal kidney tubules and the isolated toad bladder preparation1. The effects of this mineralocorticoid on sodium transport are blocked by puromycin, which prevents ribosomal protein synthesis, and by actinomycin D, which prevents the DNA-dependent elaboration of messenger RNA2,3. The consequences of increased protein synthesis due to aldosterone have been found to be a stimulation of NADH-dependent oxidative phosphorylation4 and an increased supply of acetyl CoA5. What is not clear at present is the way in which the increased metabolism influences sodium transport.
- University of Cambridge United Kingdom
Vasopressins, Sodium, Urinary Bladder, Biological Transport, Active, In Vitro Techniques, Epithelium, Stimulation, Chemical, Membrane Potentials, Theophylline, Animals, Anura, Ouabain, Pyruvates, Aldosterone
Vasopressins, Sodium, Urinary Bladder, Biological Transport, Active, In Vitro Techniques, Epithelium, Stimulation, Chemical, Membrane Potentials, Theophylline, Animals, Anura, Ouabain, Pyruvates, Aldosterone
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