Antineoplastic Activity of Aflatoxin B1

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1968 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 220, pages 931-932 (issn: 0028-0836, eissn: 1476-4687,

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Authors: S, Green;

doi: 10.1038/220931a0

pmid: 4301851

Antineoplastic Activity of Aflatoxin B1

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Abstract

THE aflatoxins, a group of related mycotoxins produced by Aspergillus flavus, have been extensively evaluated for biological activity. They are carcinogenic in animals1–5. The aflatoxin B1 fraction has been teratogenic in hamsters6, probably mutagenic in micro-organisms7 and caused chromosome breakage in mammalian cell cultures7,8. The biological activity of aflatoxin B1 was similar to that of known alkylating agents7. This investigation was undertaken to determine whether it had antineoplastic activity.

Related Organizations

United States Food and Drug Administration
United States

Keywords

Male, Carcinoma, Hepatocellular, Triethylenemelamine, Aflatoxins, Liver Neoplasms, Animals, Antineoplastic Agents, Neoplasms, Experimental, Rats

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