Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1998 English Publisher:Springer Science and Business Media LLCJournal:Nature Neuroscience, volume 1, pages 487-493 (issn: 1097-6256, eissn: 1546-1726,

Copyright policy )

Authors: T, Takahashi; F, Nakamura; Z, Jin; R G, Kalb; S M, Strittmatter;

doi: 10.1038/2203

pmid: 10196546

Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors

- Summary
- Subjects
- Metrics

Abstract

Neuropilin-1 (NP-1) has been identified as a necessary component of a semaphorin D (SemD) receptor that repulses dorsal root ganglion (DRG) axons during development. SemA and SemE are related to SemD and bind to NP-1, but do not repulse DRG axons. By expressing NP-1 in retinal neurons and NP-2 in DRG neurons, we demonstrate that neuropilins are sufficient to determine the functional specificity of semaphorin responsiveness. SemA and SemE block SemD binding to NP-1 and abolish SemD repulsion in axons expressing NP-1. SemA and SemE seem to have a newly discovered protein antagonist capacity at NP-1 receptors, whereas they act as agonists at receptors containing NP-2.

Related Organizations

Yale University
United States

Keywords

Retinal Ganglion Cells, Growth Cones, Nerve Tissue Proteins, Semaphorin-3A, Chick Embryo, Neuropilin-1, Cell Line, Mice, Ganglia, Spinal, Animals, Humans, Nerve Growth Factors, Carrier Proteins, Glycoproteins

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	221
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%