
doi: 10.1038/219238a0
pmid: 4876465
Inhibition of aminoacyl-tRNA binding by the purified initiation factors f1 and f2 could be regarded as a mechanism for ensuring that only F-met-tRNA binds initially to the entry site, thereby preventing random or non-specific binding by aminoacyl-tRNA. This inhibition would be relieved by the hydrolysis of the GTP molecule normally involved in the binding of F-met-tRNA.
Carbon Isotopes, Binding Sites, Valine, Chromatography, Ion Exchange, Tritium, Models, Biological, Guanine Nucleotides, Kinetics, Methionine, RNA, Transfer, Genetic Code, Escherichia coli, Puromycin, Amino Acids, Ribosomes
Carbon Isotopes, Binding Sites, Valine, Chromatography, Ion Exchange, Tritium, Models, Biological, Guanine Nucleotides, Kinetics, Methionine, RNA, Transfer, Genetic Code, Escherichia coli, Puromycin, Amino Acids, Ribosomes
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