Two Structurally Distinct Classes of Kappa-chains in Human Immunoglobulins

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1967 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 216, pages 262-263 (issn: 0028-0836, eissn: 1476-4687,

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Authors: H D, Niall; P, Edman;

doi: 10.1038/216262a0

pmid: 4168327

Two Structurally Distinct Classes of Kappa-chains in Human Immunoglobulins

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Abstract

THE general structural features of the various types of immunoglobulins are known and the details of the primary structure are gradually being filled in. A characteristic feature of the immune response, however, is its specificity and here the data have not been sufficient to reveal the structural basis of the specificity and even less the underlying genetic mechanism. The aim of the present investigation was to throw more light on this problem, and to this end we have determined the NH2-terminal sequences of a large number of χ-chains and made a comparison of their structures.

Keywords

Chemistry, Chemical Phenomena, Humans, Amino Acid Sequence, gamma-Globulins, Multiple Myeloma

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