Metabolism of Dihydroxyphenylalanine in Human Subjects

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1967 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 213, pages 802-803 (issn: 0028-0836, eissn: 1476-4687,

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Authors: P, Smith;

doi: 10.1038/213802a0

pmid: 6031806

Metabolism of Dihydroxyphenylalanine in Human Subjects

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Abstract

THE metabolism of dihydroxyphenylalanine (DOPA; I, R = H) may be very complex. By analogy with other amino-acids, degradation may involve decarboxylation (route A) or transamination (route B), with methylation of the 3-hydroxy group possible at any stage. The principal metabolite in normal human urine appears to be homovanillic acid (HVA; III, R = CH3), and excretion of small amounts of 3-methoxytyramine (II, R = CH3) clearly points to the operation of route A.

Keywords

Flavoring Agents, Phenylpyruvic Acids, Humans, Tyramine, Dihydroxyphenylalanine, Phenylacetates

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