Specific Antigenicity of Thymocytes

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1967 United States English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 213, pages 1,135-1,136 (issn: 0028-0836, eissn: 1476-4687,

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Authors: Potworowski, E F; Nairn, R C;

doi: 10.1038/2131135b0

pmid: 4961764

Specific Antigenicity of Thymocytes

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Abstract

THYMOCYTES (thymic lymphocytes) are believed to differ from lymphoid cells of other organs. They show a different response to a variety of physical, chemical and biological stimuli1, such as irradiation2 and phytohaemagglutinin3, and it has been claimed that they have an epithelial rather than mesenchymal origin4. In the mouse, autoantibodies5 and isoantibodies6,7 have been demonstrated with a selective toxic effect on thymocytes. The present investigation with a heterologous thymus-specific antiserum reveals rat thymocytes differing antigenically from the lymphoid cells of lymphatic circulation, lymph node and spleen.

Country

United States

Related Organizations

Monash University
Australia
Jackson Laboratory
United States

Keywords

Serology: Antigen, Immunodiffusion, Lymphoid Tissue, Immune Sera, Histological Techniques, Thymus Gland, Fluorescence, Rats, Antigen-Antibody Reactions, Mice, Liver, Microsomes, Animals, Lymph Nodes, Lymphocytes, Antigens, Strains: BALB/C, Spleen

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